Actor portrayals.
Powerful and consistent LDL-C reduction1*
*Greater LDL-C reduction was maintained during each 6-month dosing interval vs placebo as a complement to a maximally tolerated statin.1
In ORION-10 (N=1561), on top of a maximally tolerated statin
In patients with ASCVD, LEQVIO® demonstrated a 52% LDL-C reduction vs placebo with just 2 HCP-administered doses a year.1†
†After 2 initial doses.
Adults with hypercholesterolemia and ASCVD
Results were similar in patients with ASCVD in
ORION-114,5
Study Design: ORION-10 (N=1561) and ORION-11 (N=1617) were multicenter, double-blind, randomized, placebo-controlled, 18-month, phase 3 trials in adults with established ASCVD (ORION-10 and ORION-11) or increased risk for CVD‡ (ORION-11). Patients were taking a maximally tolerated statin with or without other LDL-C–modifying therapy and required additional LDL-C reduction. The primary efficacy measure was the percentage change in LDL-C from baseline to Day 510.1,7
“[My cholesterol] went down. I just had my cholesterol done…and [my bad cholesterol] is within normal range now.”
– Cindy M., LEQVIO patient compensated for her time.
Individual results may vary.
LEQVIO demonstrated consistent reduction across predefined subgroups8,9
In the ORION-1 phase 2 study, LDL-C reduction was apparent within 14 days after the first dose of LEQVIO1,10
Study Design: ORION-1 was a phase 2, multicenter, double-blinded, randomized, placebo-controlled clinical trial of 345 adults with established ASCVD who were taking a maximally tolerated statin and required additional LDL-C reduction. Of those, 91 patients received the 284-mg dose of LEQVIO. The primary efficacy end point was the percent reduction in LDL-C from baseline to Day 180 and was calculated for multiple time points at Days 14, 30, 60, 90, 120, 150, 180, 210, and 240.1,10
There's more to know about LEQVIO
See how the adherence of LEQVIO compares with PCSK9 mAbs
